Aparna's Research on Anti Hypertensive Drugs

Dear Amma, Nana and Dear All:

Here we are fine hope the same from you all.

Our research work on anti hypertensive drugs is published recently in the following journal and conference reports. These are our joint publications with Pfizer.

Have a nice day.

With love, Akkaiah.
March 23, 2006


Journal Article:

Ketopiperazine-based renin inhibitors: Optimization of the "C" ring. Holsworth Daniel D; Cai Cuiman; Cheng Xue-Min; Cody Wayne L; Downing Dennis M; Erasga Noe; Lee Chitase; Powell Noel A; Edmunds Jeremy J; Stier Michael; Jalaie Mehran; Zhang Erli; McConnell Pat; Ryan Michael J; Bryant John; Li Tingsheng; Kasani Aparna; Hall Eric; Subedi Rajendra; Rahim Mohammad; Maiti Samarendra Pfizer Global Research and Development, Michigan Laboratories, Department of Chemistry, Ann Arbor, MI 48105, USA Bioorganic & medicinal chemistry letters (2006), 16(9), 2500-4.


Conference Reports:

Discovery of novel orally bioavailable renin inhibitors by structure based drug design. Edmunds, Jeremy J.; Belliotti, Thomas; Bryant, John; Cai, Cuiman; Cheng, Xue Min; Ciske, Fred L.; Cody, Wayne L.; Collard, Wendy; Downing, Dennis M.; Erasga, Noe; Ferreira, Suzie; Hall, Eric; Holsworth, Daniel D.; Jalaie, Mehran; Kasani, Aparna; Kaufman, Michael; Lee, Chitase; Li, Tingsheng; Maiti, Samarendra; McConnell, Patrick; Mennen, Ken; Ostroski, Robert; Powell, Noel A.; Quin, John; Rahim, Mohammad; Ryan, Michael; Stier, Michael A.; Subedi, Rajandra; Van Huis, Chad; Zhang, Erli. Michigan Laboratories, Pfizer Global Research & Development, Ann Arbor, MI, USA. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006 (2006), Publisher: American Chemical Society, Washington, D. C

Ketopiperazine-based renin inhibitors: Optimization of the "C" ring: Incorporation of indole rings. Cai, Cuiman; Bryant, John; Cheng, Xue Min; Cody, Wayne L.; Collard, Wendy; Downing, Dennis M.; Erasga, Noe; Ferreira, Suzie; Hall, Eric; Holsworth, Daniel D.; Jalaie, Mehran; Kasani, Aparna Lee, Chitase; Li, Tingsheng; Maiti, Samarendra; McConnell, Patrick; Powell, Noel A.; Rahim, Mohammad; Ryan, Michael; Stier, Michael A.; Subedi, Rajandra; Zhang, Erli; Edmunds, Jeremy J. Michigan Laboratories, Pfizer Global Research & Development, Ann Arbor, MI, USA. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006 (2006), Publisher: American Chemical Society, Washington, D. C

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors. Holsworth, Daniel D.; Belliotti, Thomas; Bryant, John; Cai, Cuiman; Cody, Wayne L.; Downing, Dennis M.; Jalaie, Mehran; Kasani, Aparna; Li, Tingsheng; Maiti, Samarendra; McConnell, Patrick; Powell, Noel A.; Ryan, Michael; Subedi, Rajandra; Zhang, Erli; Edmunds, Jeremy J. Michigan Laboratories, Pfizer Global Research & Development, Ann Arbor, MI, USA. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006 (2006), Publisher: American Chemical Society, Washington, D. C